Pesquisa | BVS Integralidade em Saúde

1.

Atherosclerosis: Recent developments.

Björkegren, Johan L M; Lusis, Aldons J.

Cell ; 185(10): 1630-1645, 2022 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-35504280

2.

A vicious cycle in atherosclerosis.

Lusis, Aldons J.

Cell ; 184(5): 1139-1141, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33667367

3.

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.

Yokota, Tomohiro; McCourt, Jackie; Ma, Feiyang; Ren, Shuxun; Li, Shen; Kim, Tae-Hyung; Kurmangaliyev, Yerbol Z; Nasiri, Rohollah; Ahadian, Samad; Nguyen, Thang; Tan, Xing Haw Marvin; Zhou, Yonggang; Wu, Rimao; Rodriguez, Abraham; Cohn, Whitaker; Wang, Yibin; Whitelegge, Julian; Ryazantsev, Sergey; Khademhosseini, Ali; Teitell, Michael A; Chiou, Pei-Yu; Birk, David E; Rowat, Amy C; Crosbie, Rachelle H; Pellegrini, Matteo; Seldin, Marcus; Lusis, Aldons J; Deb, Arjun.

Cell ; 182(3): 545-562.e23, 2020 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-32621799

4.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.

Rajbhandari, Prashant; Thomas, Brandon J; Feng, An-Chieh; Hong, Cynthia; Wang, Jiexin; Vergnes, Laurent; Sallam, Tamer; Wang, Bo; Sandhu, Jaspreet; Seldin, Marcus M; Lusis, Aldons J; Fong, Loren G; Katz, Melanie; Lee, Richard; Young, Stephen G; Reue, Karen; Smale, Stephen T; Tontonoz, Peter.

Cell ; 172(1-2): 218-233.e17, 2018 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-29249357

5.

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Zhu, Weifei; Gregory, Jill C; Org, Elin; Buffa, Jennifer A; Gupta, Nilaksh; Wang, Zeneng; Li, Lin; Fu, Xiaoming; Wu, Yuping; Mehrabian, Margarete; Sartor, R Balfour; McIntyre, Thomas M; Silverstein, Roy L; Tang, W H Wilson; DiDonato, Joseph A; Brown, J Mark; Lusis, Aldons J; Hazen, Stanley L.

Cell ; 165(1): 111-124, 2016 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-26972052

6.

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.

Wang, Zeneng; Roberts, Adam B; Buffa, Jennifer A; Levison, Bruce S; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K; DiDonato, Anthony J; Fu, Xiaoming; Hazen, Jennie E; Krajcik, Daniel; DiDonato, Joseph A; Lusis, Aldons J; Hazen, Stanley L.

Cell ; 163(7): 1585-95, 2015 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-26687352

7.

Mammary duct luminal epithelium controls adipocyte thermogenic programme.

Patel, Sanil; Sparman, Njeri Z R; Arneson, Douglas; Alvarsson, Alexandra; Santos, Luís C; Duesman, Samuel J; Centonze, Alessia; Hathaway, Ephraim; Ahn, In Sook; Diamante, Graciel; Cely, Ingrid; Cho, Chung Hwan; Talari, Noble Kumar; Rajbhandari, Abha K; Goedeke, Leigh; Wang, Peng; Butte, Atul J; Blanpain, Cédric; Chella Krishnan, Karthickeyan; Lusis, Aldons J; Stanley, Sarah A; Yang, Xia; Rajbhandari, Prashant.

Nature ; 620(7972): 192-199, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37495690

8.

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages.

Orozco, Luz D; Bennett, Brian J; Farber, Charles R; Ghazalpour, Anatole; Pan, Calvin; Che, Nam; Wen, Pingzi; Qi, Hong Xiu; Mutukulu, Adonisa; Siemers, Nathan; Neuhaus, Isaac; Yordanova, Roumyana; Gargalovic, Peter; Pellegrini, Matteo; Kirchgessner, Todd; Lusis, Aldons J.

Cell ; 151(3): 658-70, 2012 Oct 26.

Artigo em Inglês | MEDLINE | ID: mdl-23101632

9.

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.

Keinan, Omer; Valentine, Joseph M; Xiao, Haopeng; Mahata, Sushil K; Reilly, Shannon M; Abu-Odeh, Mohammad; Deluca, Julia H; Dadpey, Benyamin; Cho, Leslie; Pan, Austin; Yu, Ruth T; Dai, Yang; Liddle, Christopher; Downes, Michael; Evans, Ronald M; Lusis, Aldons J; Laakso, Markku; Chouchani, Edward T; Rydén, Mikael; Saltiel, Alan R.

Nature ; 599(7884): 296-301, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34707293

10.

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.

Xiong, Xuelian; Kuang, Henry; Ansari, Sahar; Liu, Tongyu; Gong, Jianke; Wang, Shuai; Zhao, Xu-Yun; Ji, Yewei; Li, Chuan; Guo, Liang; Zhou, Linkang; Chen, Zhimin; Leon-Mimila, Paola; Chung, Meng Ting; Kurabayashi, Katsuo; Opp, Judy; Campos-Pérez, Francisco; Villamil-Ramírez, Hugo; Canizales-Quinteros, Samuel; Lyons, Robert; Lumeng, Carey N; Zhou, Beiyan; Qi, Ling; Huertas-Vazquez, Adriana; Lusis, Aldons J; Xu, X Z Shawn; Li, Siming; Yu, Yonghao; Li, Jun Z; Lin, Jiandie D.

Mol Cell ; 75(3): 644-660.e5, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31398325

11.

Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.

Wang, Yu-Chen; Koay, Yen Chin; Pan, Calvin; Zhou, Zhiqiang; Tang, Wilson; Wilcox, Jennifer; Li, Xinmin S; Zagouras, Alexia; Marques, Francine; Allayee, Hooman; Rey, Federico E; Kaye, David M; O'Sullivan, John F; Hazen, Stanley L; Cao, Yang; Lusis, Aldons J.

Circ Res ; 134(4): 371-389, 2024 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-38264909

12.

TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis.

Govatati, Suresh; Kumar, Raj; Boro, Monoranjan; Traylor, James G; Orr, A Wayne; Lusis, Aldons J; Rao, Gadiparthi N.

J Biol Chem ; 300(5): 107224, 2024 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-38537695

13.

An integrative systems genetic analysis of mammalian lipid metabolism.

Parker, Benjamin L; Calkin, Anna C; Seldin, Marcus M; Keating, Michael F; Tarling, Elizabeth J; Yang, Pengyi; Moody, Sarah C; Liu, Yingying; Zerenturk, Eser J; Needham, Elise J; Miller, Matthew L; Clifford, Bethan L; Morand, Pauline; Watt, Matthew J; Meex, Ruth C R; Peng, Kang-Yu; Lee, Richard; Jayawardana, Kaushala; Pan, Calvin; Mellett, Natalie A; Weir, Jacquelyn M; Lazarus, Ross; Lusis, Aldons J; Meikle, Peter J; James, David E; de Aguiar Vallim, Thomas Q; Drew, Brian G.

Nature ; 567(7747): 187-193, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30814737

14.

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H; Moreau, Pierre R; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J; Heikkinen, Sami; Romanoski, Casey E; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.

Am J Hum Genet ; 108(3): 411-430, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33626337

15.

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis.

Massey, William J; Varadharajan, Venkateshwari; Banerjee, Rakhee; Brown, Amanda L; Horak, Anthony J; Hohe, Rachel C; Jung, Bryan M; Qiu, Yunguang; Chan, E Ricky; Pan, Calvin; Zhang, Renliang; Allende, Daniela S; Willard, Belinda; Cheng, Feixiong; Lusis, Aldons J; Brown, J Mark.

J Lipid Res ; 64(4): 100349, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36806709

16.

Gene Regulatory Networks in Coronary Artery Disease.

Cheng, Jenny; Cheng, Michael; Lusis, Aldons J; Yang, Xia.

Curr Atheroscler Rep ; 25(12): 1013-1023, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38008808

17.

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".

Rau, Christoph D; Gonzales, Natalia M; Bloom, Joshua S; Park, Danny; Ayroles, Julien; Palmer, Abraham A; Lusis, Aldons J; Zaitlen, Noah.

PLoS Genet ; 16(10): e1009165, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33104702

18.

Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism.

von Scheidt, Moritz; Zhao, Yuqi; de Aguiar Vallim, Thomas Q; Che, Nam; Wierer, Michael; Seldin, Marcus M; Franzén, Oscar; Kurt, Zeyneb; Pang, Shichao; Bongiovanni, Dario; Yamamoto, Masayuki; Edwards, Peter A; Ruusalepp, Arno; Kovacic, Jason C; Mann, Matthias; Björkegren, Johan L M; Lusis, Aldons J; Yang, Xia; Schunkert, Heribert.

Circulation ; 143(18): 1809-1823, 2021 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-33626882

19.

RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice.

Karunakaran, Denuja; Nguyen, My-Anh; Geoffrion, Michele; Vreeken, Dianne; Lister, Zachary; Cheng, Henry S; Otte, Nicola; Essebier, Patricia; Wyatt, Hailey; Kandiah, Joshua W; Jung, Richard; Alenghat, Francis J; Mompeon, Ana; Lee, Richard; Pan, Calvin; Gordon, Emma; Rasheed, Adil; Lusis, Aldons J; Liu, Peter; Matic, Ljubica Perisic; Hedin, Ulf; Fish, Jason E; Guo, Liang; Kolodgie, Frank; Virmani, Renu; van Gils, Janine M; Rayner, Katey J.

Circulation ; 143(2): 163-177, 2021 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-33222501

20.

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits.

Raulerson, Chelsea K; Ko, Arthur; Kidd, John C; Currin, Kevin W; Brotman, Sarah M; Cannon, Maren E; Wu, Ying; Spracklen, Cassandra N; Jackson, Anne U; Stringham, Heather M; Welch, Ryan P; Fuchsberger, Christian; Locke, Adam E; Narisu, Narisu; Lusis, Aldons J; Civelek, Mete; Furey, Terrence S; Kuusisto, Johanna; Collins, Francis S; Boehnke, Michael; Scott, Laura J; Lin, Dan-Yu; Love, Michael I; Laakso, Markku; Pajukanta, Päivi; Mohlke, Karen L.

Am J Hum Genet ; 105(4): 773-787, 2019 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-31564431

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